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Results Found: 7
  • NYU Dataset

    Mass Spectrometry Data Suggests Mitovesicles are Altered in Down Syndrome

    Authors
    Pasquale D'Acunzo
    Rocío Pérez-González
    Yohan Kim
    Tal Hargash
    11 more author(s)...
    Description

    This dataset showed that mitovesicles, extracellular vesicles (EVs) of mitochondrial origin, are altered in Down syndrome (DS). Mitochondrial dysfunction is a distinctive feature of aging and neurodegenerative disorders, such as DS and Alzheimer’s disease. For this study, a high-resolution density gradient separation of EVs isolated from murine and human DS and diploid control brains was used. Using...

    Subject
    Genomics
    Proteomics
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    Free to All

  • National Alzheimer’s Coordinating Center Data

    Alternate Title(s)
    NACC
    Description

    The National Alzheimer’s Coordinating Center (NACC) was created in 1999 to facilitate research with data collected from Alzheimer's Disease Research Centers (ADRCs) across the United States. NACC oversees data collection and sharing for a number of datasets. The Uniform Data Set (UDS) contains longitudinal and standardized data collected from ADRCs since 2005. ADRC enrollment protocols vary and...

    Subject
    Chronic Disease
    Mental Health
    Neuroscience
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    Free to All
    Application Required
    Author Approval Required
    Local Expert
    Omonigho M. Bubu
    Ricardo Osorio
  • NYU Dataset

    Profiling Basal Forebrain Cholinergic Neurons Reveals Vulnerability Within the Mouse Model of Down Syndrome and Alzheimer’s Disease

    Authors
    Melissa J. Alldred
    Sai C. Penikalapati
    Sang Han Lee
    Adriana Heguy
    2 more author(s)...
    Description

    Basal forebrain cholinergic neuron (BFCN) degeneration is an indicator of Down syndrome (DS) and Alzheimer’s disease (AD). The Ts65Dn (Ts) mouse model recapitulates both cognitive and morphological deficits of DS and AD, including BFCN degeneration. Therefore, this study used Ts mice to understand mechanisms underlying BFCN degeneration to identify novel targets for therapeutic intervention. They performed...

    Subject
    Neuroscience
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    Author Approval Required
  • NYU Dataset

    Oxidative Phosphorylation Is Dysregulated Within the Basocortical Circuit in Mouse Model of Down Syndrome and Alzheimer’s Disease

    Authors
    Melissa J. Alldred
    Sang Han Lee
    Grace E. Stutzmann
    Stephen D. Ginsberg
    Description

    Neurological dysfunction associated with Down syndrome (DS) is the concomitant basal forebrain cholinergic neuron (BFCN) degeneration and onset of Alzheimer’s disease (AD) pathology. Previously, single population RNA sequencing analysis in the Ts65Dn (Ts) mouse model of DS revealed that the mitochondrial oxidative phosphorylation pathway was significantly impacted, where a large subset of genes within...

    Subject
    Neuroscience
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    Author Approval Required
  • NYU Dataset

    Mammalian Target of Rapamycin (mTOR) Hyperactivation in Down Syndrome Results in Mitophagy Deficiency

    Authors
    Matteo Bordi
    Sandipkumar Darji
    Yutaka Sato
    Marian Mellen
    4 more author(s)...
    Description

    Down syndrome (DS) is linked with mitochondrial dysfunction, which results in accumulation of damaged mitochondria. This study revealed that mitophagy, a form of selective autophagy activated to clear damaged mitochondria, is deficient in primary human fibroblasts derived from individuals with DS. This leads to accumulation of damaged mitochondria with consequent increases in oxidative stress. They...

    Subject
    Genomics
    Neuroscience
    Access Rights
    Free to All
  • NYU Dataset

    Long-Term Effects of Maternal Choline Supplementation on Gene Expression in Mouse Model of Down Syndrome and Alzheimer’s Disease

    Authors
    Melissa J. Alldred
    Helen M. Chao
    Sang Han Lee
    Judah Beilin
    4 more author(s)...
    Description

    Choline is a vital nutrient that is used by the body to produce acetylcholine, which is an important neurotransmitter essential for brain and nervous system functions. Therefore, sufficient intake of dietary choline is important for proper brain function and neurodevelopment. It is especially critical for brain development during the perinatal period. This study investigated the impact of perinatal...

    Subject
    Neuroscience
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  • NYU Dataset

    Lysosomal Dysfunction in Down Syndrome Is APP-Dependent and Mediated by APP-βCTF

    Authors
    Ying Jiang
    Yutaka Sato
    Eunju Im
    Martin J. Berg
    8 more author(s)...
    Description

    Lysosomal failure plays an important role in the pathogenesis of many congenital neurodegenerative disorders, such as Alzheimer’s disease (AD) and Down syndrome (DS). This study showed that lysosomal dysfunction in DS requires the extra gene copy of amyloid precursor protein (APP) and is specifically mediated by the β cleaved carboxy terminal fragment of APP (APP-βCTF). In primary fibroblasts from...

    Subject
    Genomics
    Neuroscience
    Access Rights
    Free to All